Protein community - Organization and maintenance of protein functions

Cellular proteins constitute a ‘protein community’ with both spatial and temporal order, and are under the control of intricate systems to achieve and maintain their functions and organizations.  By employing these systems, the protein community delivers proteins to specific sites of functions, assists their correct folding/assembly, monitors their functional quality, and executes risk-management programs.  Constituents of those systems include molecular chaperones, protein translocators, ERAD/UPR-related proteins etc., which function coordinately in the integrated and comprehensive networks.  This project aims at understanding the molecular basis of those systems and revealing biological consequences of their system failure, thereby expanding the frontier of the newly developing ‘in vivo protein science’.